Phosphosphingosine
WebDec 19, 2024 · Product Name: phospho-Sphingosine Kinase 2 (Thr-578) Type: Blocking Peptide Elisa: 50 ng/well WB: Background: Sphingolipids are metabolized into bioactive products that include ceramide, sphingosine, and sphingosine-1-phosphate (S1P). Sphingosine Kinase (SK) catalyzes the phosphorylation of the lipid sphingosine, creating … WebPhospho-Threonine/Tyrosine Antibody detects proteins and peptides phosphorylated at threonine and tyrosine residues in a manner largely independent of the surrounding amino acid sequence. The antibody is phospho-specific and may cross-react slightly with some phospho-serine-containing sequences. By ELISA, it recognizes a wide variety of ...
Phosphosphingosine
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WebSphingosine-1-phosphate ( S1P) is a signaling sphingolipid, also known as lysosphingolipid. It is also referred to as a bioactive lipid mediator. Sphingolipids at large form a class of lipids characterized by a particular aliphatic aminoalcohol, which is sphingosine . Production [ edit] WebPhospho-sphingosine kinase 1 Breast cancer Lymphatic metastasis HER2 Inflammation abstract Background: Sphingosine-1-phosphate (S1P), a pleiotropic bioactive lipid mediator, has been implicated as a key regulatory molecule in cancer through its ability to promote cell pro-liferation, migration, angiogenesis, and lymphangiogenesis.
WebSPHK1 Antibodies Antibodies that detect SPHK1 can be used in several scientific applications, including Western Blot, Immunohistochemistry, Immunocytochemistry, Immunoprecipitation and ELISA. These antibodies target SPHK1 in Human, Mouse, Rat, Non-human primate and Bovine samples. WebFeb 1, 2024 · Sphingosine-1-phosphate (S1P) is a pleiotropic bioactive lipid mediator, which produced by sphingosine kinase 1 (SphK1) activated by phosphorylation. The SphK1-S1P axis has a crucial role in...
WebTwo major sphingoid bases of fungi – dihydrosphingosine and phosphosphingosine, induced ROS accumulation and cell death with typical markers of apoptosis in Aspergillus nidulans (Cheng et al., 2003). Greater understanding of PCD in pathogenic fungi may offer a chance of exploiting the fungal death machinery to control fungal infections. WebBackground: Sphingosine-1-phosphate (S1P), a pleiotropic bioactive lipid mediator, has been implicated as a key regulatory molecule in cancer through its ability to promote cell proliferation, migration, angiogenesis, and lymphangiogenesis.
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WebOct 22, 2024 · We recently identified the sphingosine kinases (SphK1/2) as key intracellular regulators of immunogenic cell death (ICD) in colorectal cancer (CRC) cells. To better understand the mechanism by which SphK inhibition enhances ICD, we focused on the intracellular signaling pathways leading to cell surface exposure of calreticulin (ectoCRT). … patrircaWebSphingosine, the metabolic product of Cer, can itself be converted to sphingosine 1-phosphate (S1P; Igarashi, 1997 ), which is known to be a ligand of the G-protein-coupled receptors, S1P 1 –S1P 5, and to be involved in apoptosis inhibition, angiogenesis, and cell migration ( Kihara, Mitsutake, Mizutani, & Igarashi, 2007 ). patrisha nichole cortezWebThe production of IGF-1 is stimulated by growth hormone (GH) and can be retarded by undernutrition, growth hormone insensitivity, lack of growth hormone receptors, or failures of the downstream signaling pathway post GH receptor including SHP2 and STAT5B. Recombinant human IGF-1 are globular proteins containing 70 amino acids and 3 intra ... patrisha cortezWebPhosphosphingosine. 2 types of phospholipids in membrane. Phospholipid that is also a sphingolipid. Phosphosphingosine is a type of: Glycerol backbone 2 FA chains 3rd chain = HEAD = PO4 + alcohol ... patri serviceWebOct 20, 2024 · A zwitterionic clickable lipid, azidoethylcholine phosphosphingosine (Figure 4.2) could show better plasma membrane (PM) localisation, as indicated by Klymchenko et al., where their zwitterionic... patrisha nicole genatoWebThe major phosphosphingolipids of mammals are sphingomyelins (ceramide phosphocholines), which consist of a ceramide unit linked at position 1 to phosphorylcholine; From: Liquid Chromatography: Applications, 2013 Sphingolipid Biosynthesis Martina Leipelt, Alfred H. MerrillJr., in Encyclopedia of Biological Chemistry, … patriot xm channelWebPhospho-Sphingosine Kinase 1 Expression in Lymphatic Spread of Esophageal Squamous Cell Carcinoma. J Surg Res. 2024; 234:123-131 (ISSN: 1095-8673) Nemoto M; Ichikawa H; Nagahashi M; Hanyu T; Ishikawa T; Kano Y; Muneoka Y; Wakai T. BACKGROUND: Lymphatic spread is the main mode of progression of esophageal squamous cell carcinoma (ESCC). patrisha collins