Imp-1/crd-bp function

Author: awbe

August undefined, 2024

Witryna9 paź 2013 · High levels of CRD-BP that are found in primary human colorectal tumours exhibiting active beta-catenin/Tcf signalling implicates CRD-BP induction in the upregulation of beta TrCP1, in the ... Witryna18 maj 2010 · Molecular Function: translation regulator activity Source:BHF-UCL. 1 publication. ... IMP-1; IMP1. Alternative names. Coding region determinant-binding …

IMP-1 Recombinant Protein - Cat. No. 39-901 ProSci

Witryna6 paź 2001 · CRD‐BP/IMP‐1 belongs to a family of RNA‐binding proteins containing 2 RRMs and 4 KH domains; it plays a role in the posttranscriptional control of both … WitrynaPlasmid pIS1 IMP-1 long UTR from Dr. David Bartel's lab contains the insert IGF-II mRNA-binding protein 1 UTR and is published in Cell. 2009 Aug 21. 138(4):673-84. ... (a.k.a. CRD-BP, CRDBP, IMP-1, IMP1, VICKZ1, ZBP1) ... Long means that all functional alternative polyadenylation signals have been deleted. simplonblick

Expression of oncofetal RNA‐binding protein CRD‐BP/IMP1 …

Witryna29 sie 2024 · Introduction. Insulin-like growth factor II mRNA-binding protein 1 (IGF2BP1/IMP1), also known as the c-Myc coding region determinant-binding protein (CRD-BP) and zipcode-binding protein 1 (ZBP1), is a multifunctional RNA-binding protein that binds to diverse cancer-associated mRNAs to promote mRNA stability, … Witryna19 lis 2004 · Thus, we have identified a dominant function for CRD-BP in cell proliferation of human K562 cells, involving a possible IGF-II-dependent mechanism … Witryna20 cze 2024 · The biphasic expression of IMP/Vg1-RBP is conserved between vertebrates and Drosophila. Mech. Dev. (2000) ... on the understanding of the oncogenic mechanism of CRD-BP as well as in the future design of inhibitors against CRD-BP function.Coding region determinant-binding protein (CRD-BP) interacts physically … ray-nuh fpt-130

Addgene: pMSCV PIG IMP-1-short

Witryna31 lip 2009 · Similarly, the half-life of a GBG mutant lacking an miR-183-binding site was not affected by CRD-BP, as compared to GBG containing the wild-type 577–1182 nt fragment of βTrCP1 (Figure 3 E). Knockdown of CRD-BP reduced expression of βTrCP1, but failed to do so when the function of miR-183 was inhibited (Figure 4 A). WitrynaIGF2BP1. Insulin-like growth factor 2 mRNA-binding protein 1 is a protein that in humans is encoded by the IGF2BP1 gene. [5] [6] [7] This gene encodes a member of the IGF … simplon chenoa bosch cx 2021Witryna9 kwi 2024 · CRD-BP has a dominant role in proliferation of human K562 cells by an IGF-II-dependent mechanism independent of its ability to serve as a c-myc … simplon bus

"WitrynaIMP-1 Recombinant Protein (Cat. No. 39-901) has been validated for use in E and WB. ... ZBP1, CRDBP, IMP-1, CRD-BP, VICKZ1, Insulin-like growth factor 2 mRNA-binding protein 1, Coding region determinant ... The cookie is set by GDPR cookie consent to record the user consent for the cookies in the category "Functional". cookielawinfo … " - Imp-1/crd-bp function

Imp-1/crd-bp function

WitrynaInsulin -like growth factor II mRNA-binding protein, CRD-BP, VICKZ1), IMP-2 (IMP2, VICKZ2, p62) and IMP-3 (KOC1, VICKZ3), contain a unique combination of RNA recognition motifs and four hnRNP K homology domains. IMP-1 is abundant in embryonal tissues and in 81% of colon cancers, 58.5% of breast Witryna31 sty 2007 · CRD-BP protects the c-myc CRD and MDR-1 RNA from cleavage by the mammalian endoribonuclease. Having established that recombinant CRD-BP can bind c-myc CRD and MDR-1 RNA, we then sought to determine if the binding of CRD-BP to RNA could directly protect these transcripts from degradation by an endoribonuclease …

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WitrynaUpper panel, analysis by gel electrophoresis of CRD-BP/IMP1 amplicons. 1, BM CD34 cells cultured in plain medium; 2, medium containing 5azaC; 3, medium containing the cytokines mixture; 4, medium ... WitrynaCRD-BP belongs to a family of RNA binding proteins that show close a relation to the chicken β-actin zipcode-binding protein ZBP1[1] and the human forms of the protein …

Witrynapreferentially to distinct CRD-BP KH domains. The novel insights revealed in this study have important implications on the understanding of the oncogenic mechanism of CRD-BP a well as in the future design of inhibitors against CRD-BP function. Coding region determinant-binding protein (CRD-BP; mouse), also known as IMP1 (human), WitrynaPlasmid pIS1 IMP-1 long UTR from Dr. David Bartel's lab contains the insert IGF-II mRNA-binding protein 1 UTR and is published in Cell. 2009 Aug 21. 138(4):673-84. ...

Witryna25 maj 2007 · CRD-BP/IMP-1 expression in HCT116 colon cancer cells (a) and adult human colon (b–e).Immunohistochemistry was performed as described in the Material and methods section by either using a rabbit anti-CRD-BP/IMP1 antibody (a and e), or by using a goat anti CRD-BP/IMP-1 antibody (b–d).In normal mucosa (b, d, e) CRD … WitrynaPlasmid pMSCV PIG IMP-1-long-mut from Dr. David Bartel's lab contains the insert IGF-II mRNA-binding protein 1 and is published in Cell. 2009 Aug 21. 138(4):673-84. ... (a.k.a. CRD-BP, CRDBP, IMP-1, IMP1, VICKZ1, ZBP1) ... Long means that all functional alternative polyadenylation signals have been deleted.

Witryna15 cze 2006 · CRD-BP function seems to be important for the pathogenesis of human colorectal ... P. et al. C-MYC and IGF-II mRNA-binding protein (CRD-BP/IMP-1) in benign and malignant mesenchymal tumors. Int. ...

WitrynaPlasmid pMSCV PIG IMP-1-long-mut from Dr. David Bartel's lab contains the insert IGF-II mRNA-binding protein 1 and is published in Cell. 2009 Aug 21. 138(4):673-84. ... (a.k.a. CRD-BP, CRDBP, IMP-1, IMP1, … ray nugent regency apartments tequesta flWitryna7 sty 2011 · CRD-BP was shown to upregulate the expression of different genes including c-myc, 13 β-TrCP1, 10 MDR1, 14 and GLI1. 15 It was also shown to be necessary for proper cell adhesion, cytoplasmic spreading, and invadopodia formation through its binding to the 3′UTR of CD44 mRNA and stabilization of the mRNA. In … raynsway properties limitedWitrynaDownload scientific diagram siRNA-mediated reduction of CRD-BP/IMP1 mRNA levels . A, efficiency of siRNA uptake by MCF-7 cells. MCF-7 cells were transfected with a control non-silencing ... simplon by microsoftWitrynaCRD-BP was shown to upregulate the expression of different genes including c-myc, 13 β-TrCP1, 10 MDR1, 14 and GLI1. 15 It was also shown to be necessary for proper … simplon bicycleWitryna1 paź 2010 · Europe PMC is an archive of life sciences journal literature. Introduction. CRD-BP, the coding region determinant binding protein, also known as insulin-like growth factor 2 mRNA-binding protein 1 (IMP-1 or IGF2BP-1), is a multifunctional RNA binding protein involved in different processes such as mRNA turnover, translation control, … simplonblick raronWitrynaMouse coding region determinant–binding (mCRD‐BP) and human IGF‐II mRNA–binding 1 (hIMP‐1) proteins are orthologous mRNA‐binding proteins that recognize c‐myc and IGF‐II mRNA, respectively, and regul... simplon chenoa bosch cx gewichtWitryna4 cze 2007 · The probability of differences in overall survival as a function of time was determined by Kaplan–Meier test, with probing for significance by applying log-rank … simplon chenoa bosch cx damen